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1994-09-03
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Document 0119
DOCN M9490119
TI AIDS-free survival and overall survival in HIV infection: the new CDC
classification system (1993) for HIV disease and AIDS.
DT 9411
AU Kamps BS; Brodt HR; Staszewski S; Bergmann L; Helm EB; Medizinische
Klinik III, Universitatsklinik Frankfurt, Germany.
SO Clin Investig. 1994 Mar;72(4):283-7. Unique Identifier : AIDSLINE
MED/94319111
AB The clinical history of 1538 HIV positive patients was analyzed on the
basis of the new CDC classification system of HIV disease and AIDS. This
classification system combines three CD4 cell categories (1, 2, and 3)
with three clinical categories (A, B, and C) into nine subgroups A1-C3.
We examined the overall survival for all subgroups and the AIDS-free
survival for subgroups A1-B3. AIDS-free survival for patients in
subgroups A1, A2, and B1 was considerably longer than survival in
patients from subgroups A3, B2, and B3 (P < 0.0001). According to these
findings, the new CDC classification system could be simplified into
three stages, stage I and II comprising the above mentioned six
subgroups, and stage III comprising clinical AIDS defining categories
C1, C2, and C3. These three stages correspond to different periods in
the management of HIV positive patients, i.e., period of observation,
period of prophylaxis, and period of treatment.
DE Acquired Immunodeficiency Syndrome/*CLASSIFICATION Centers for Disease
Control and Prevention (U.S.) Human HIV
Infections/*CLASSIFICATION/MORTALITY Prognosis Survival Analysis
United States JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).